BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF)

“A major component in this gift of neurogenesis—and it is a gift to be revered—is a protein called brain-derived neurotrophic factor (BDNF), which, as we read in previous chapters, plays a key role in creating new neurons. And it also protects existing neurons, helping to ensure their survivability while encouraging synapse formation—that is, the connection of one neuron to another—which is vital for thinking, learning, and higher levels of brain function. Studies have in fact demonstrated that BDNF levels are lower in Alzheimer’s patients, which is no surprise, given our current understanding of how BDNF works...

We now have a very firm understanding of the factors that influence our DNA to produce BDNF. Fortunately, these factors are by and large under our direct control. Increasing your production of BDNF and thus increasing neurogenesis while adding protection to your existing brain neurons doesn’t require that you enroll in a research study to determine if some new laboratory-created compound will enhance BDNF production. The gene that turns on BDNF is activated by a variety of factors, including voluntary physical exercise—animals forced to exercise do not demonstrate this change, calorie reduction, intellectual stimulation, curcumin, and the omega-3 fat known as docosahexaenoic acid.

This is a powerful message because all of these factors are within our grasp; they represent choices we can make to turn on the gene for neurogenesis.”

- David Perlmutter & Alberto Villoldo from Power Up Your Brain